Posters
Finger Stick Self-Collection of Maternal Blood for Non-Invasive Prenatal Testing
International Society for Prenatal Diagnosis – March 2017
Prenatal diagnosis of fetal gender from self-collected capillary blood is simple, accurate, and reliable. The results of this study demonstrate that fetal DNA analysis using self-collected capillary blood is highly feasible and easily adaptable for population screening. This method simplifies blood collection of maternal blood and should increase the accessibility of noninvasive prenatal testing.
Maternal Capillary Blood: A New Source of Circulating Cell-Free Fetal DNA for Non-Invasive Prenatal Testing
The American Society of Human Genetics – October 2015
Noninvasive prenatal testing (NIPT) is currently limited to maternal venous blood collection by trained phlebotomists. We conducted the first evaluation of self-collected capillary blood samples for the determination of fetal sex. Pregnant women (11-37 weeks gestation) self-collected capillary blood samples by lancet finger stick. Y-chromosome specific sequences were detected in capillary blood samples in all pregnancies confirmed to have a male fetus. All gender results were in concordance with known fetal sex, without false-positive or false-negative results. For fetal sex, self-collected capillary blood samples and venous blood samples from pregnant women produced a sensitivity of 100%, specificity of 100% and accuracy of 100%.
Maternal Capillary Blood: A New Source of Circulating Cell-Free Fetal DNA for Non-Invasive Prenatal Testing
The International Society for Prenatal Diagnosis – July 2015
This study identifies a new source of cell-free fetal DNA and demonstrates its utility for noninvasive prenatal diagnosis using maternal capillary blood. Maternal capillary blood samples were obtained from pregnant women (6-24 weeks gestation) by finger stick. Cell-free DNA was detected in all maternal capillary blood samples. Y-chromosome specific sequences were detected in all (100%) pregnancies confirmed to have a male fetus. All gender results were in concordance with known fetal sex, without false-positive or false-negative results. Prenatal diagnosis of fetal gender from maternal capillary blood is simple, accurate, and reliable.